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This suggests that children and adolescents may be able to regenerate myocardium, that abnormal cardiomyocyte proliferation may be involved in myocardial diseases that affect this population, and that these diseases might be treatable through stimulation of cardiomyocyte proliferation. The only currently available, definitive therapy—heart transplantation—is limited by donor availability.

New approaches, such as cell transplantation, have shown encouraging results in clinical trials (5, 6).

The percentages of cardiomyocytes in mitosis and cytokinesis were highest in infants, decreasing to low levels by 20 y.

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